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PD 118057

Cat. No. 2830 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2830 has been discontinued.

View all Voltage-gated Potassium (K<sub>V</sub>) Channels products.
说明： Selective KV11.1 (hERG) channel activator
化学名： 2-[[4-[2-(3,4-Dichlorophenyl)ethyl]phenyl]amino]benzoic acid
纯度： ≥99% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for PD 118057

PD 118057 is a human ether-a-go-go (hERG) KV11.1 potassium channel activator. Displays no major effect on INa, ICa/L, IK1 and IKs currents. Causes resting membrane hyperpolarization and decreases action potential duration in rat myocytes in vitro.

技术数据 for PD 118057

分子量 386.27
公式 C21H17Cl2NO2
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 2830313674-97-4
PubChem ID 9864959
InChI Key ZCQOSCDABPVAFB-UHFFFAOYSA-N
Smiles ClC(C(Cl)=C3)=CC=C3CCC(C=C2)=CC=C2NC1=C(C(O)=O)C=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for PD 118057

参考文献是支持产品生物活性的出版物。

Zhou et al (2005) Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity. Mol.Pharmacol. 68 876 PMID: 15976038

Yeung and Greenwood (2007) Pharmacological and biophysical isolation of K+ currents encoded by ether-a-go-go-related genes in murine hepatic portal vein smooth muscle cells. Am.J.Physiol.Cell.Physiol. 292 C468 PMID: 16870833

Duff (2008) hERG: The long and short of it. Heart Rhythm 5 591 PMID: 18362028

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关键词: PD 118057, PD 118057 supplier, Human, ether-a-go-go, hERG, K+, potassium, KV, channels, activators, voltage-gated, voltage-dependent, PD118057, KV11.1, Voltage-Gated, Potassium, Channels, 2830, Tocris Bioscience

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Amazing Kv channel activator.
By Anonymous on 10/23/2018
分析类型： In Vitro
种属： Human

Amazing Kv channel activator, shows high channel activation on almost all cell lines that express Kv channels. Performs great on experimental conditions, is stable and would buy again soon.

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