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说明： Photoswitchable TRPC3/6/7 agonist
化学名： 1-[1-[4-[4-[(4-Butylphenyl)diazenyl]phenyl]butanoyl]piperidin-4-yl]-1,3-dihydro-2H-benzo[d]imidazol-2-one
纯度： ≥98% (HPLC)
生物活性 for OptoBI-1
OptoBI-1 is a photoswitchable TRPC3/6/7 agonist (EC50 for active cis-form ~0.1 μM at TRPC3). Switches conformation from trans to cis at 365 nm and cis to trans at 430 nm. Returns to trans conformation in the dark after ~ 50 minutes. No effect observed on TRPC4 or 5. Rapidly changes TRPC3 conductance and inhibits neuronal firing in cis-state.
技术数据 for OptoBI-1
| 分子量 | 523.67 |
| 公式 | C32H37N5O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2415272-11-4 |
| InChI Key | LUASQYYRQCWOMA-XAHDOWKMSA-N |
| Smiles | CCCCC1=CC=C(/N=N/C2=CC=C(C=C2)CCCC(N3CCC(N4C(NC5=CC=CC=C45)=O)CC3)=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for OptoBI-1
参考文献 for OptoBI-1
参考文献是支持产品生物活性的出版物。
Tiapko et al (2019) Lipid-independent control of endothelial and neuronal TRPC3 channels by light. Chem.Sci. 10 2837
Curcic et al (2019) Photopharmacology and opto-chemogenetics of TRPC channels-some therapeutic visions. Pharmacol.Ther. 200 13 PMID: 30974125
Curcic et al (2019) TRPC-mediated Ca2+ signaling and control of cellular functions. Semin.Cell Dev.Biol. 94 28 PMID: 30738858
Lichtenegger et al (2018) An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel. Nat.Chem.Biol. 14 396 PMID: 29556099
关键词: OptoBI-1, OptoBI-1 supplier, OptoBI1, PhotoswitchableTRPC3, TRPC6, TRPC7, agonists, agonism, ligands, Photoswitchable, Ligands, TRPC, 7013, Tocris Bioscience
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