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NX 1607

Cat. No. 8950 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： CBL-B intramolecular glue inhibitor
化学名： 2,3-Dihydro-2-[3-[cis-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-6-[[(3S)-3-methyl-1-piperidinyl]methyl]-4-(trifluoromethyl)-1H-isoindol-1-one
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NX 1607

NX 1607 (Cbl-b-IN-3) is an inhibitor of CBL-B (Casitas B-lineage lymphoma proto-oncogene B), a RING-type E3 ubiquitin ligase. NX 1607 acts as an intramolecular glue. In vitro, NX 1607 activates MAPK/ERK signaling pathway and enhances T-cell activation in primary T cells and Jurkat T cells. In vivo, NX 1607 decreases tumor growth in cell lymphoma models. NX 1607 is orally bioavailable.

许可信息

Sold under license from Nurix Therapeutics

技术数据 for NX 1607

分子量 537.63
公式 C30H34F3N5O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2573775-59-2
PubChem ID 155449671
InChI Key HUOLMBXGHHSYHC-QWQFASRJSA-N
Smiles CN1C([C@@]2(C3=CC(N4CC5=C(C(F)(F)F)C=C(CN6C[C@H](CCC6)C)C=C5C4=O)=CC=C3)C[C@H](C2)C)=NN=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NX 1607

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 10.75 20
ethanol 53.76 100

制备储备液 for NX 1607

以下数据基于产品分子量 537.63。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.86 mL 9.3 mL 18.6 mL
5 mM 0.37 mL 1.86 mL 3.72 mL
10 mM 0.19 mL 0.93 mL 1.86 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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参考文献 for NX 1607

参考文献是支持产品生物活性的出版物。

Zhu et al (2025) Cbl-b inhibitor NX-1607 activates MAPK/ERK signaling pathway and enhances T-cell activation. J.Immunother.Cancer 13 e011180 PMID: 40447319

If you know of a relevant reference for NX 1607, please let us know.

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关键词: NX 1607, NX 1607 supplier, NX1607, NX-1607, Cbl-b-IN-3, E3, ubiquitin, ligase, intramolecular, glue, in, vivo, orally, bioavailable, lymphoma, MAPK/ERK, signaling, pathway, T-cell, activation, Ubiquitin, Ligases, Molecular, Glues, 8950, Tocris Bioscience

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

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