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Cat.No. 6089 - Nexinhib20 | C15H16N4O3 | CAS No. 331949-35-0
说明: Rab27 inhibitor; inhibits neutrophil exocytosis; active in vivo
化学名: 4,4-Dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one
纯度: ≥98% (HPLC)

生物活性 for Nexinhib20

Nexinhib20 is a Rab27 inhibitor (IC50 = 330 nM); inhibits Rab27a-JFC1 binding. Selectively inhibits neutrophil exocytosis, with no significant effect on other important innate immune responses including phagocytosis. Suppresses extracellular production of superoxide anion and cytochrome b plasma membrane expression. Also inhibits upregulation of adhesion molecules CD11b and CD66b. Displays in vivo anti-inflammatory activity.

化合物库 for Nexinhib20

Nexinhib20 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Nexinhib20

分子量 300.31
公式 C15H16N4O3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 331949-35-0
PubChem ID 5715188
Smiles CC(C)(C(/C(N1C=NC=N1)=C/C2=CC([N+]([O-])=O)=CC=C2)=O)C


Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Nexinhib20

溶剂 最高浓度 mg/mL 最高浓度 mM
DMSO 30.03 100
ethanol 15.02 50

制备储备液 for Nexinhib20

以下数据基于产品分子量 300.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.33 mL 16.65 mL 33.3 mL
5 mM 0.67 mL 3.33 mL 6.66 mL
10 mM 0.33 mL 1.66 mL 3.33 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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参考文献 for Nexinhib20


Johnson et al (2016) Identification of neutrophil exocytosis inhibitors (Nexinhibs), small molecule inhibitors of neutrophil exocytosis and inflammation: druggability of the small GTPase Rab27a. J.Biol.Chem. 291 25965 PMID: 27702998

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关键词: Nexinhib20, Nexinhib20 supplier, Rab27, inhibitors, inhibits, Rab27a-JFC1, binding, neutrophil-specific, exocytosis, anti-inflammatory, Nexinhib, 20, Other, Small, Monomeric, GTPases, 6089, Tocris Bioscience

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