Nexinhib20

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Cat.No. 6089 - Nexinhib20 | C15H16N4O3 | CAS No. 331949-35-0
说明: Rab27 inhibitor; inhibits neutrophil exocytosis; active in vivo
化学名: 4,4-Dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one
纯度: ≥98% (HPLC)
说明书
引用文献
评论

生物活性 for Nexinhib20

Nexinhib20 is a Rab27 inhibitor (IC50 = 330 nM); inhibits Rab27a-JFC1 binding. Selectively inhibits neutrophil exocytosis, with no significant effect on other important innate immune responses including phagocytosis. Suppresses extracellular production of superoxide anion and cytochrome b plasma membrane expression. Also inhibits upregulation of adhesion molecules CD11b and CD66b. Displays in vivo anti-inflammatory activity.

化合物库 for Nexinhib20

Nexinhib20 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Nexinhib20

分子量 300.31
公式 C15H16N4O3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 331949-35-0
PubChem ID 5715188
InChI Key VKSOIYNNOFGGES-JYRVWZFOSA-N
Smiles CC(C)(C(/C(N1C=NC=N1)=C/C2=CC([N+]([O-])=O)=CC=C2)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Nexinhib20

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.03 100
ethanol 15.02 50

制备储备液 for Nexinhib20

以下数据基于产品分子量 300.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.33 mL 16.65 mL 33.3 mL
5 mM 0.67 mL 3.33 mL 6.66 mL
10 mM 0.33 mL 1.66 mL 3.33 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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参考文献 for Nexinhib20

参考文献是支持产品生物活性的出版物。

Johnson et al (2016) Identification of neutrophil exocytosis inhibitors (Nexinhibs), small molecule inhibitors of neutrophil exocytosis and inflammation: druggability of the small GTPase Rab27a. J.Biol.Chem. 291 25965 PMID: 27702998


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关键词: Nexinhib20, Nexinhib20 supplier, Rab27, inhibitors, inhibits, Rab27a-JFC1, binding, neutrophil-specific, exocytosis, anti-inflammatory, Nexinhib, 20, Other, Small, Monomeric, GTPases, 6089, Tocris Bioscience

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