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说明： NLRP3 inflammasome inhibitor
化学名： (T4)-[2-Acetyl-4,4,4-trichloro-3-(imino-κN)butanamidito-κO]diphenylboron
纯度： ≥98% (HPLC)
生物活性 for NBC 6
NBC 6 is a NLRP3 inflammasome inhibitor (IC50 = 574 nM). Inhibits nigericin-induced inflammasome activation in THP-1 cells and Imiquimod (Cat. No. 3700) induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs).
许可信息
Sold under license from the University of Manchester.
技术数据 for NBC 6
| 分子量 | 409.5 |
| 公式 | C18H16BCl3N2O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2068818-02-8 |
| PubChem ID | 145237739 |
| InChI Key | VKECODDKRKQJNM-UHFFFAOYSA-N |
| Smiles | CC(C1=C(C(Cl)(Cl)Cl)N[B-](C2=CC=CC=C2)(C3=CC=CC=C3)[O+]=C1N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NBC 6
参考文献 for NBC 6
参考文献是支持产品生物活性的出版物。
Baldwin et al (2017) Boron-based inhibitors of the NLRP3 inflammasome. Cell Chem.Biol. 24 1321 PMID: 28943355
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关键词: NBC 6, NBC 6 supplier, NBC6, inflammasome, inhibitors, inhibits, NLRP3, Inflammasomes, 6925, Tocris Bioscience
NBC 6 的评论
平均评分: 5 (Based on 1 Review.)
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NBC 6 can efficiently block pyroptosis induction.
By
Xiaogang Wang on 06/12/2020
分析类型： In Vitro
种属： Human
细胞系/组织： THP-1 cells
We ordered this product, combining with another pyroptosis inhibitor NSA, to confirm the induction of pyroptosis by staphylococcal virulence factors. We have shown that NSA significantly inhibited the release of LDH by THP-1 cells treated with staphylococcal products. To confirm that tested staphylococcal product induces pyroptosis, we also used 20 uM NBC 6 to pretreat THP-1 cells before incubating with staphylococcal product. Similarly, treatment of THP-1 cells with NBC 6 also significantly decreased the release of LDH in THP-1 cells treated by staphylococcal product.
