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NBC 19

Cat. No. 6722 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6722 has been discontinued.

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说明： Potent NLRP3 inflammasome inhibitor
化学名： (T4)-[2-Acetyl-4,4,4-trichloro-N-cyclohexyl-3-(imino-κN)butanamidato-κO]diphenylboron
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for NBC 19

NBC 19 is a potent NLRP3 inflammasome inhibitor (IC50 = 60-80 nM). Inhibits nigericin- and ATP-induced IL-1β release.

许可信息

Sold under license from the University of Manchester.

技术数据 for NBC 19

分子量 491.64
公式 C24H26BCl3N2O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2068818-75-5
InChI Key XLUPBOKHLVUFLX-UHFFFAOYSA-N
Smiles CC(C1=C(C(Cl)(Cl)Cl)N[B-](C2=CC=CC=C2)(C3=CC=CC=C3)[O+]=C1NC4CCCCC4)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for NBC 19

参考文献是支持产品生物活性的出版物。

Baldwin et al (2017) Boron-Based Inhibitors of the NLRP3 Inflammasome. Cell Chem.Biol. 24 1321 PMID: 28943355

Redondo-Castro et al (2018) Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses. Sci.Rep. 8 5667 PMID: 29618797

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关键词: NBC 19, NBC 19 supplier, NBC19, Potent, NLRP3, inhibitors, inhibits, inflammasome, Inflammasomes, 6722, Tocris Bioscience

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