MO-I-500

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Cat.No. 6871 - MO-I-500 | C12H12ClNO5S | CAS No. 1585219-04-0
说明: FTO inhibitor; anticonvulsant
化学名: N-[5-(4-Chlorophenyl)-3,4-dihydroxy-2-furanyl]ethanesulfonamide
纯度: ≥98% (HPLC)
说明书
引用文献
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生物活性 for MO-I-500

MO-I-500 is a FTO inhibitor (IC50 = 8.7 μM for purified FTO in vitro), which increases N6-methyladenosine (m6A) levels in total cellular mRNA in HeLa cells. MO-I-500 modulates levels of specific miRNAs. In a triple-negative breast cancer cell line metabolically challenged by culture without glutamine (SUM149-MA cells), MO-I-500 inhibits cell proliferation. MO-I-500 also displays anticonvulsant activity in a 6 Hz mouse model of epilepsy at nontoxic doses.

技术数据 for MO-I-500

分子量 317.75
公式 C12H12ClNO5S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1585219-04-0
PubChem ID 73505416
InChI Key WWHUSZQHRUNRSB-UHFFFAOYSA-N
Smiles CCS(=O)(NC1=C(C(O)=C(C2=CC=C(C=C2)Cl)O1)O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MO-I-500

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 31.77 100

制备储备液 for MO-I-500

以下数据基于产品分子量 317.75。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.74 mL 31.47 mL
5 mM 0.63 mL 3.15 mL 6.29 mL
10 mM 0.31 mL 1.57 mL 3.15 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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参考文献 for MO-I-500

参考文献是支持产品生物活性的出版物。

Zheng et al (2014) Synthesis of a FTO inhibitor with anticonvulsant activity. ACS.Chem.Neurosci. 5 658 PMID: 24834807

Singh et al (2016) Important role of FTO in the survival of rare panresistant triple-negative inflammatory breast cancer cells facing a severe metabolic challenge. PLoS One. 11 PMID: 27390851


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关键词: MO-I-500, MO-I-500 supplier, FTO, inhibitors, inhibits, anticonvulsant, mRNA, N6-methyladenine, demethylase, α, alfa, alpha-ketoglutarate-dependent, dioxygenase, fat, mass, and, obesity-associated, protein, Other, Oxygenases/Oxidases, 6871, Tocris Bioscience

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