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Cat.No. 6871 - MO-I-500 | C12H12ClNO5S | CAS No. 1585219-04-0
说明: FTO inhibitor; anticonvulsant
化学名: N-[5-(4-Chlorophenyl)-3,4-dihydroxy-2-furanyl]ethanesulfonamide
纯度: ≥98% (HPLC)

生物活性 for MO-I-500

MO-I-500 is a FTO inhibitor (IC50 = 8.7 μM for purified FTO in vitro), which increases N6-methyladenosine (m6A) levels in total cellular mRNA in HeLa cells. MO-I-500 modulates levels of specific miRNAs. In a triple-negative breast cancer cell line metabolically challenged by culture without glutamine (SUM149-MA cells), MO-I-500 inhibits cell proliferation. MO-I-500 also displays anticonvulsant activity in a 6 Hz mouse model of epilepsy at nontoxic doses.

技术数据 for MO-I-500

分子量 317.75
公式 C12H12ClNO5S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1585219-04-0
PubChem ID 73505416
Smiles CCS(=O)(NC1=C(C(O)=C(C2=CC=C(C=C2)Cl)O1)O)=O


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溶解性数据 for MO-I-500

溶剂 最高浓度 mg/mL 最高浓度 mM
DMSO 31.77 100

制备储备液 for MO-I-500

以下数据基于产品分子量 317.75。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.74 mL 31.47 mL
5 mM 0.63 mL 3.15 mL 6.29 mL
10 mM 0.31 mL 1.57 mL 3.15 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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参考文献 for MO-I-500


Zheng et al (2014) Synthesis of a FTO inhibitor with anticonvulsant activity. ACS.Chem.Neurosci. 5 658 PMID: 24834807

Singh et al (2016) Important role of FTO in the survival of rare panresistant triple-negative inflammatory breast cancer cells facing a severe metabolic challenge. PLoS One. 11 PMID: 27390851

If you know of a relevant reference for MO-I-500, please let us know.



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关键词: MO-I-500, MO-I-500 supplier, FTO, inhibitors, inhibits, anticonvulsant, mRNA, N6-methyladenine, demethylase, α, alfa, alpha-ketoglutarate-dependent, dioxygenase, fat, mass, and, obesity-associated, protein, Other, Oxygenases/Oxidases, 6871, Tocris Bioscience

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