LM11A 31 dihydrochloride

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Cat.No. 5046 - LM11A 31 dihydrochloride | C12H25N3O2.2HCl | CAS No. 1243259-19-9
说明: Nonpeptide p75NTR ligand; neuroprotective
化学名: (2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide dihydrochloride
纯度: ≥95% (HPLC)
文献 (6)

生物活性 for LM11A 31 dihydrochloride

LM11A 31 dihydrochloride is a nonpeptide p75NTR ligand and nerve growth factor (NGF) antagonist. LM11A 31 blocks p75-mediated cell death, inhibits proNGF induced cell death (IC50 = 1-10 nM), increases proliferation and survival of hippocampal neural progenitors and inhibits Aβ-induced cell death (EC50 = 20 nM). In animal models of Alzheimer's disease LM11A 31 prevents and reverses atrophy of cholinergic neurites and reverses Alzheimer's pathology; in models of Huntington's disease LM11A 31 increases survival, reduces the formation of aggregates of mutant huntingtin and neuronal degeneration. Also promotes functional recovery in a mouse model of spinal cord injury. Orally available and brain penetrant.

技术数据 for LM11A 31 dihydrochloride

分子量 316.27
公式 C12H25N3O2.2HCl
储存 Desiccate at RT
纯度 ≥95% (HPLC)
CAS Number 1243259-19-9
PubChem ID 91654620
Smiles O=C([C@@H](N)[C@@H](C)CC)NCCN1CCOCC1.Cl.Cl


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溶解性数据 for LM11A 31 dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
water 31.63 100
DMSO 31.63 100

制备储备液 for LM11A 31 dihydrochloride

以下数据基于产品分子量 316.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.81 mL 31.62 mL
5 mM 0.63 mL 3.16 mL 6.32 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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产品说明书 for LM11A 31 dihydrochloride

参考文献 for LM11A 31 dihydrochloride


Shi et al (2013) A small molecule P75NTR ligand protects neurogenesis after traumatic brain injury. Stem Cells [Epub ahead of print] PMID: 23940017

Massa et al (2006) Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death. J.Neurosci. 26 5288 PMID: 6707781

Tep et al (2013) Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury. J.Neurosci. 33 397 PMID: 23303920

Simmons et al (2014) A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One 9 e102136 PMID: 25153701

Simmons et al (2016) A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice. Hum.Mol.Genet. 25 4920 PMID: 28171570

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关键词: LM11A 31 dihydrochloride, LM11A 31 dihydrochloride supplier, LM11A31, dihydrochloride, p75NTR, ligands, selective, NGFR, nerve, growth, factor, receptors, Alzheimer's, Disease, neuroprotective, Trk, Receptors, Neuronal, Metabolism, 5046, Tocris Bioscience

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