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Cat.No. 1378 - Levcromakalim | C16H18N2O3 | CAS No. 94535-50-9
说明: Kir6 (KATP) channel opener; active enantiomer of Cromakalim
别名: BRL 38227
化学名: (3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
纯度: ≥99% (HPLC)
引用文献 (3)
评论 (1)
文献 (3)

生物活性 for Levcromakalim

Levcromakalim is an active enantiomer of the prototypical Kir6 (KATP) channel opener Cromakalim. Hypotensive and airways relaxant. IC50 = 490 nM in guinea pig trachea.


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技术数据 for Levcromakalim

分子量 286.33
公式 C16H18N2O3
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 94535-50-9
PubChem ID 93504
Smiles O=C1CCCN1[C@H]2[C@H](O)C(C)(C)OC3=C2C=C(C#N)C=C3


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溶解性数据 for Levcromakalim

溶剂 最高浓度 mg/mL 最高浓度 mM
DMSO 2.86 10

制备储备液 for Levcromakalim

以下数据基于产品分子量 286.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 34.92 mL 174.62 mL 349.25 mL
0.5 mM 6.98 mL 34.92 mL 69.85 mL
1 mM 3.49 mL 17.46 mL 34.92 mL
5 mM 0.7 mL 3.49 mL 6.98 mL

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参考文献 for Levcromakalim


Buckle et al (1991) Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols. J.Med.Chem. 34 919 PMID: 2002472

Noack et al (1992) Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227). Br.J.Pharmacol. 107 945 PMID: 1467843

Taylor et al (1992) The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways. J.Pharmacol.Exp.Ther. 261 429 PMID: 1578358

If you know of a relevant reference for Levcromakalim, please let us know.

关键词: Levcromakalim, Levcromakalim supplier, KATP, channel, openers, Potassium, KIR, Channels, Inward, Rectifier, K+, BRL38227, BRL, 38227, rectifier, 1378, Tocris Bioscience

3 篇 Levcromakalim 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Levcromakalim 的部分引用包括:

Fike et al (2013) Reactive oxygen species scavengers improve voltage-gated K(+) channel function in pulmonary arteries of newborn pigs with progressive hypoxia-induced pulmonary hypertension. Pulm Circ 3 551 PMID: 24618540

Garland et al (2015) TRPM4 inhibitor 9-phenanthrol activates endothelial cell intermediate conductance calcium-activated potassium channels in rat isolated mesenteric artery. Br J Pharmacol 172 1114 PMID: 25323322

Fransen et al (2015) Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. Lab Chip 10 e0121634 PMID: 25803863

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Levcromakalim was used on BK channel opening properties compared to cromakalim.
By Anonymous on 11/28/2018
分析类型: In Vitro
种属: Human

Levcromakalim was used on our lab to understand its BK channel opening properties compared to cromakalim. Results were reproducible.

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