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Submit ReviewLaulimalide
说明： Microtubule stabilzing agent
别名： Fijianolide B
化学名： (1R,3S,7S,8S,10S,12S,15Z,18R)-12-[(1S,2E)-3-[(2S)-3,6-dihydro-4-methyl-2H-pyran-2-yl]-1-hydroxy-2-propen-1-yl]-7-hydroxy-3-methyl-5-methylene-9,13,22-trioxatricyclo[16.3.1.08,10]docosa-15,19-dien-14-one
纯度： ≥97% (HPLC)
生物活性 for Laulimalide
Laulimalide is a microtubule stabilizing agent. Potent inhibitor of cellular proliferation in cancer cell lines (IC50 reported to be 3-30 nM, dependent on cell line used). Causes cells to arrest in the prometaphase of the cell cycle, prevents formation of bipolar spindle and increases kinetochore tension in preformed spindles.
技术数据 for Laulimalide
| 分子量 | 514.65 |
| 公式 | C30H42O7 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 115268-43-4 |
| PubChem ID | 6918457 |
| InChI Key | MSBQEQDLFWWWMV-XZZGLLCESA-N |
| Smiles | O=C(O[C@H]([C@@H](O)/C=C/[C@]1([H])CC(C)=CCO1)C[C@]2([H])O[C@@]2([H])[C@@H](O)C3)/C=C\C[C@]4([H])C=CC[C@](C[C@@H](C)CC3=C)([H])O4 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Laulimalide
参考文献 for Laulimalide
参考文献是支持产品生物活性的出版物。
Pryor et al (2002) The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to PacT. and epothilones, and may not require its epoxide moiety for activity. Biochemistry. 41 9109 PMID: 12119025
Bennett et al (2012) Low-dose laulimalide represents a novel molecular probe for investigating microtubule organization. Cell Cycle. 11 3045 PMID: 22871740
Bennett et al (2010) Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping. Chem.Biol. 17 725 PMID: 20659685
关键词: Laulimalide, Laulimalide supplier, Laulimalide, Fijianolide, B, microtubule, stabilizers, stabilizing, agents, cell, proliferation, inhibitors, Microtubules, 4007, Tocris Bioscience
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets