主页 / 药理学 / Enzymes / Ligases / DNA Ligases / DNA Ligase Inhibitors / L189

L189

Cat. No. 3561 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3561 has been discontinued.

View all DNA Ligases products.
说明： DNA ligase I, III and IV inhibitor
化学名： 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
说明书
引用文献 (1)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for L189

L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.

技术数据 for L189

分子量 246.29
公式 C11H10N4OS
储存 Store at -20°C
CAS Number 64232-83-3
PubChem ID 824710
InChI Key SAKOXVNKDMWWLF-UHFFFAOYSA-N
Smiles S=C1NC(N)=C(/N=C/C2=CC=CC=C2)C(N1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for L189

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for L189

参考文献是支持产品生物活性的出版物。

Chen et al (2008) Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 68 3169 PMID: 18451142

按标靶查看相关产品

按产品操作查看相关产品

查看全部 DNA Ligase Inhibitors

关键词: L189, L189 supplier, DNA, ligases, I, III, IV, 1, 3, 4, inhibitors, inhibits, Ligases, 3561, Tocris Bioscience

1 篇 L189 的引用文献

引用文献是使用了 Tocris 产品的出版物。 L189 的部分引用包括：

Kempegowda et al (2018) Autocyclized and oxidized forms of SCR7 induce cancer cell death by inhibiting nonhomologous DNA end joining in a Ligase IV dependent manner. FEBS J 285 3959-3976 PMID: 30230716

L189 的评论

目前没有该产品的评论。 Be the first to review L189 and earn rewards!

Have you used L189?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review