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KH CB19

Cat. No. 4262 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4262 has been discontinued.

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说明： Selective, potent inhibitor of CLK1 and 4
化学名： Ethyl 3-(2-Amino-1-cyanoethenyl)-6,7-dichloro-1-methylindole-2-carboxylate
纯度： ≥97% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for KH CB19

Selective, potent inhibitor of CDC2-like kinase (CLK) 1 and 4 (IC50 = 20 nM for CLK1). Suppresses serine/arginine-rich protein phosphorylation by CLKs under proinflammatory conditions. Displays selectivity over a panel of 71 protein kinases. ATP-competitive.

技术数据 for KH CB19

分子量 338.19
公式 C15H13Cl2N3O2
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 1354037-26-5
Smiles ClC1=C(N(C)C(C(OCC)=O)=C2/C(C#N)=C\N)C2=CC=C1Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for KH CB19

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参考文献 for KH CB19

参考文献是支持产品生物活性的出版物。

Fedorov et al (2011) Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem.Biol. 18 67 PMID: 21276940

Boltzen et al (2012) Alternatively spliced tissue factor and full-length tissue factor protect cardiomyocytes against TNF-α-induced apoptosis. J.Mol.Cell.Cardiol. 52 1056 PMID: 22326437

Eisenreich et al (2013) Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells. Oncol.Rep. 30 462 PMID: 23604472

Knapp et al (2013) A public-private partnership to unlock the untargeted kinome. Nat.Chem.Biol. 9 3 PMID: 23238671

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关键词: KH CB19, KH CB19 supplier, KHCB19, CLK1, inhibitors, inhibits, CDC2-like, kinase, CLKs, CLK4, CLK, (Cdc2-like, kinases), 4262, Tocris Bioscience

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