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JX 06

Cat. No. 5845 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5845 has been discontinued.

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说明： Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor
化学名： Bis(morpholinothiocarbonyl) disulfide
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for JX 06

JX 06 is a potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor (IC50 values are 49, 101 and 313 nM for PDK1, PDK2 and PDK3, respectively). Exhibits selectivity for PDK1/2/3 over PDK4 and a panel of 323 other kinases. Suppresses A549 lung cancer cell proliferation in vitro. Reduces tumor volume of A549 xenografts in mice.

技术数据 for JX 06

分子量 324.51
公式 C10H16N2O2S4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 729-46-4
PubChem ID 12892
InChI Key KKVYOWPPMNSLCP-UHFFFAOYSA-N
Smiles S=C(SSC(N1CCOCC1)=S)N2CCOCC2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for JX 06

参考文献是支持产品生物活性的出版物。

Sun et al (2015) JX06 selectively inhibits pyruvate dehydrogenase kinase PDK1 by a covalent cysteine modification. Cancer Res. 75 4923 PMID: 26483203

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关键词: JX 06, JX 06 supplier, NSC402538, JX06, potent, selective, PDK1, PDK2, PDK3, pyruvate, dehydrogenase, kinases, inhibitors, inhibits, Other, Kinases, 5845, Tocris Bioscience

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