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IMP 2373

Cat. No. 8171 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： pan-DUB activity-based probe with alkyne click handle
化学名： 4-(1-Cyanopyrrolidine-3-carbonyl)-N-[(4-ethynylphenyl)methyl]-1-methylpyrrole-2-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for IMP 2373

IMP 2373 is a pan-deubiquitinase (pan-DUB) activity-based probe with alkyne click handle. IMP 2373 interacts with more than 35 DUBs in diverse cell lines and across a range of non-toxic concentrations. IMP 2373 can be used to monitor changes in intracellular DUB activity in live cells during pharmacological inhibition and in vivo during MYC deregulation in a model of B cell lymphoma.

技术数据 for IMP 2373

分子量 360.42
公式 C21H20N4O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
PubChem ID 169494136
InChI Key URHCOQKMCOCJCX-UHFFFAOYSA-N
Smiles C#CC1=CC=C(CNC(C2=CC(C(C3CN(C#N)CC3)=O)=CN2C)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for IMP 2373

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.04 100
ethanol 36.04 100

制备储备液 for IMP 2373

以下数据基于产品分子量 360.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.87 mL 27.75 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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参考文献 for IMP 2373

参考文献是支持产品生物活性的出版物。

Conole et al (2023) Discovery of a potent Deubiquitinase (DUB) small-molecule activity-based probe enables broad spectrum DUB activity profiling in living cells. Angew Chem.Int.Ed.Engl. 62 e202311190 PMID: 37779326

If you know of a relevant reference for IMP 2373, please let us know.

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关键词: IMP 2373, IMP 2373 supplier, IMP2373, IMP-2373, DUB, DUBs, activity, probes, activity-based, probe, ABP, in, vivo, alkyne, click, handle, Deubiquitinating, Enzymes, 8171, Tocris Bioscience

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