Fenoprofen calcium

Name: Fenoprofen calcium
Brand: Tocris Bioscience
SKU: 6926

Cat. No. 6926 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6926 has been discontinued.

View all Melanocortin (MC) Receptors products.

说明： Positive allosteric modulator of MC₃ receptors; exhibits biased signaling

化学名： α-Methyl-3-phenoxybenzeneacetic acid hemicalcium salt

纯度： ≥98% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Fenoprofen calcium

Fenoprofen calcium is a melanocortin 3 (MC₃) receptor positive allosteric modulator (PAM; allosteric enhancer) (pEC₅₀ = 8.69); decreases the EC₅₀ of α-MSH at MC₃R. Stimulates ERK1/2 activation at MC₃_-5R, with highest ERK1/2 activation observed at 3 and 10 μM for MC₃R, 1 μM for MC₄R, and 3 μM for MC₅R. Exhibits biased signaling at MC₃_-5R, selectively activating ERK1/2 cascade but not canonical cAMP signaling. Antiarthritic.

技术数据 for Fenoprofen calcium

分子量	261.31
公式	C₁₅H₁₃O₃.0.5Ca
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	34597-40-5
PubChem ID	64746
InChI Key	VHUXSAWXWSTUOD-UHFFFAOYSA-L
Smiles	CC(C1=CC=CC(OC2=CC=CC=C2)=C1)C([O-])=O.CC(C3=CC=CC(OC4=CC=CC=C4)=C3)C([O-])=O.[Ca+2]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Fenoprofen calcium

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Fenoprofen calcium

参考文献是支持产品生物活性的出版物。

Yuan et al (2019) Fenoprofen-an old drug rediscovered as a biased allosteric enhancer for melanocortin receptors. ACS Chem.Neurosci. 10 1066 PMID: 30168706

Montero-Melendez et al (2017) Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3 Cell Mol.Life Sci. 74 1335 PMID: 27853832

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关键词: Fenoprofen calcium, Fenoprofen calcium supplier, 71720-56-4, 71720564, Melanocortin, 3, MC3, receptor, positive, allosteric, modulators, PAMs, enhancers, biased, signaling, antiarthritic, anti-inflamatory, NSAID, Receptors, 6926, Tocris Bioscience

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