[D-Arg¹,D-Phe⁵,D-Trp^7,9,Leu¹¹]-Substance P

Name: [D-Arg 1 ,D-Phe 5 ,D-Trp 7,9 ,Leu 11 ]-Substance P
Brand: Tocris Bioscience
SKU: 1946

Cat. No. 1946 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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1946 has been discontinued.

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说明： Potent ghrelin receptor inverse agonist; Antagonist at other neuropeptide receptors

说明书

引用文献 (3)

文献 (1)

生物活性技术数据说明书参考文献

生物活性

[D-Arg¹,D-Phe⁵,D-Trp^7,9,Leu¹¹]-Substance P is a broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC₅₀ = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. Induces apoptosis and inhibits cancer cell growth in vitro.

技术数据

分子量	1516.85
公式	C₇₉H₁₀₉N₁₉O₁₂
序列	RPKPFQWFWLL (Modifications: Arg-1 = D-Arg, Phe-5 = D-Phe, Trp-7 = Trp-9 = D-Trp, Leu-11 = C-terminal amide)
储存	Desiccate at -20°C
CAS Number	96736-12-8
PubChem ID	25091011
InChI Key	XVOCEQLNJQGCQG-ACRSGXKRSA-N
Smiles	[H]N[C@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

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参考文献

参考文献是支持产品生物活性的出版物。

Holst et al (2003) High constitutive signaling of the ghrelin receptor - identification of a potent inverse agonist. Mol.Endocrinol. 17 2201 PMID: 12907757

Jarpe et al (1998) [D-Arg¹, D-Phe⁵, D-Trp^7,9, Leu¹¹] Substance P acts as a biased agonist toward neuropeptide and chemokine receptors. J.Biol.Chem. 273 3097 PMID: 9446627

Reeve and Bleehen (1994) [D-Arg¹, D-Phe⁵, D-Trp^7,9, Leu¹¹] Substance P induces apoptosis in lung cancer cells in vitro. Biochem.Biophys.Res.Commun. 199 1313 PMID: 7511895

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关键词: [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P supplier, Substance, P, broad, spectrum, neuropeptide, receptor, antagonists, inverse, agonists, Potent, ghrelin, Tachykinin, Neurokinin, Receptors, GHS-R1a, Growth, Hormone, Secretagog, Receptor, 1a, Ghrelin, [D-Arg1D-Phe5D-Trp79Leu11]-SubstanceP, neuropeptides, Other, 1946, Tocris Bioscience

3 篇 [D-Arg¹,D-Phe⁵,D-Trp^7,9,Leu¹¹]-Substance P 的引用文献

引用文献是使用了 Tocris 产品的出版物。 [D-Arg¹,D-Phe⁵,D-Trp^7,9,Leu¹¹]-Substance P 的部分引用包括：

Torres-Fuentes et al (2014) Devil's Claw to suppress appetite--ghrelin receptor modulation potential of a Harpagophytum procumbens root extract. Oncotarget 9 e103118 PMID: 25068823

Schellekens et al (2013) Promiscuous dimerization of the GH secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling. J Biol Chem 288 181 PMID: 23161547

Pastor-Cavada et al (2016) A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity In vivo Scientific Reports 6 36456 PMID: 27819353