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CRBN PROTAC® 14a
生物活性 for CRBN PROTAC® 14a
CRBN PROTAC® 14a is a cereblon Degrader (PROTAC®). Comprises a ligand for Von Hippel Lindau (VHL) protein joined by a linker to a cereblon targeting ligand. Preferentially degrades cereblon (DC50 = 200 nM in HEK293 cells). Induces rapid and profound cereblon degradation (98% decrease after 8 h at 1 μM in HEK293 cells).
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Sold under licence from the University of Dundee
技术数据 for CRBN PROTAC® 14a
|储存||Store at -20°C|
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CRBN PROTAC® 14a
|溶剂||最高浓度 mg/mL||最高浓度 mM|
制备储备液 for CRBN PROTAC® 14a
以下数据基于产品分子量 1061.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|浓度/溶剂体积/质量||1 mg||5 mg||10 mg|
|1 mM||0.94 mL||4.71 mL||9.42 mL|
|5 mM||0.19 mL||0.94 mL||1.88 mL|
|10 mM||0.09 mL||0.47 mL||0.94 mL|
|50 mM||0.02 mL||0.09 mL||0.19 mL|
参考文献 for CRBN PROTAC® 14a
Girardini et al (2019) Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs. Bioorg.Med.Chem. 27 2466 PMID: 30826187
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关键词: CRBN PROTAC® 14a, CRBN PROTAC® 14a supplier, PROTACs, PROTAC, proteolysis, targeting, chimera, active, Degrader, Degraders, degrading, VHL, von, Hippel, Lindau, Cereblon, CRBN, targeted, protein, degradation, TPD, Active, Ubiquitin, E3, Ligases, 7219, Tocris Bioscience
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