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说明： GluN2B-selective NMDA antagonist
生物活性 for Conantokin G
Conantokin G is a GluN2B (formally NR2B) selective, competitive antagonist of the NMDA receptor. Blocks NMDA-evoked current in mouse cortical neurons (IC50 = 480 nM); also inhibits NMDA-evoked responses in oocytes expressing GluN2B (formally NR2B), but not GluN2A (formally NR2A), subunits (IC50 ~300 nM). Exhibits neuroprotective properties in vivo and in vitro.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
技术数据 for Conantokin G
| 分子量 | 2264.21 |
| 公式 | C88H138N26O44 |
| 序列 |
GEXXLQXNQXLIRXKSN (Modifications: X = Gla, Asn-17 = C-terminal amide) |
| 储存 | Store at -20°C |
| CAS Number | 93438-65-4 |
| PubChem ID | 16132376 |
| InChI Key | HTBKFGWATIYCSF-UHFFFAOYSA-N |
| Smiles | CCC(C)C(NC(=O)C(CC(C)C)NC(=O)C(CC(C(O)=O)C(O)=O)NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CC(C(O)=O)C(O)=O)NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C(O)=O)C(O)=O)NC(=O)C(CC(C(O)=O)C(O)=O)NC(=O)C(CCC(O)=O)NC(=O)CN)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC(C(O)=O)C(O)=O)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CC(N)=O)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Conantokin G
参考文献 for Conantokin G
参考文献是支持产品生物活性的出版物。
Donevan and McCabe (2000) Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors. Mol.Pharmacol. 58 614 PMID: 10953056
Bush et al (2000) Selective antagonism of nigral neuropeptide responses to metha. by conantokin G, a naturally occurring conopeptide. Eur.J.Pharmacol. 387 55 PMID: 10633160
Williams et al (2000) Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies. J.Pharmacol.Exp.Ther. 294 378 PMID: 10871336
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关键词: Conantokin G, Conantokin G supplier, neuroprotective, NMDA, receptors, antagonists, NR2B, selective, venoms, GluN2B, Receptors, 4136, Tocris Bioscience
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