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说明： Positive allosteric modulator of M1 receptors
化学名： 1,4-Dihydro-1-[(4-methoxyphenyl)methyl]-4-oxo-3-quinolinecarboxylic acid
纯度： ≥98% (HPLC)
生物活性 for BQCA
BQCA is a muscarinic M1 receptor positive allosteric modulator (pKB 5.76 - 5.82). Exhibits selectivity for M1 over M3 and M5 receptors. Enhances ACh effects at M1 receptors in an IP1- accumulation assay, without affecting ACh binding. Increases markers of neuronal activation in brains of wild-type but not M1-/- mice in vivo. Prevents Scopolamine (Cat. No. 1414)-induced memory deficits in mice in a contextual fear conditioning model.
技术数据 for BQCA
| 分子量 | 309.32 |
| 公式 | C18H15NO4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 338747-41-4 |
| PubChem ID | 1476756 |
| InChI Key | BZBBTGCKPRSPGF-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(CN2C=C(C(O)=O)C(=O)C3=CC=CC=C23)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BQCA
参考文献 for BQCA
参考文献是支持产品生物活性的出版物。
Khajehali et al (2018) Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor. Biochem.Pharmacol 154 243 PMID: 29777683
Ma et al (2009) Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation. Proc.Natl.Acad.Sci.U.S.A. 106 15950 PMID: 19717450
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关键词: BQCA, BQCA supplier, benzyl, quinolone, carboxylic, acid, muscarinic, M1, mAChR, positive, allosteric, modulator, PAM, Receptors, 6872, Tocris Bioscience
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