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Submit ReviewBML-190
说明： Potent, selective CB2 ligand
别名： Indomethacin morpholinylamide,IMMA
化学名： 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1-[2-(4-morpholinyl)-2-oxoethyl]-1H-indole
纯度： ≥99% (HPLC)
生物活性 for BML-190
Potent and selective CB2 receptor ligand (Ki values are 435 nM and > 2 μM for CB2 and CB1 respectively).
技术数据 for BML-190
| 分子量 | 426.9 |
| 公式 | C23H23ClN2O4 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 2854-32-2 |
| PubChem ID | 2415 |
| InChI Key | BJSDNVVWJYDOLK-UHFFFAOYSA-N |
| Smiles | COC1=CC=C2N(C(=O)C3=CC=C(Cl)C=C3)C(C)=C(CC(=O)N3CCOCC3)C2=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BML-190
参考文献 for BML-190
参考文献是支持产品生物活性的出版物。
Melck et al (2000) Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. Endocrinology 141 118 PMID: 10614630
Gallant et al (1996) New class of potent ligands for the human peripheral cannabinoid receptor. Bioorg.Med.Chem.Lett. 6 2263
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关键词: BML-190, BML-190 supplier, Potent, selective, CB2, ligands, Cannabinoid, Receptors, cb2r, Indomethacin, morpholinylamide, IMMA, 1383, Tocris Bioscience
1 篇 BML-190 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BML-190 的部分引用包括：
Zhang et al (2010) In vitro metabolism of indomet. morpholinylamide (BML-190), an inverse agonist for the peripheral cannabinoid receptor (CB(2)) in rat liver microsomes. Eur J Pharm Sci 41 163 PMID: 20542112
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.