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说明： Potent and selective adrenergic α2B antagonist
化学名： 1-[2-[[[3-(3,5-Dimethyl-4-isoxazolyl)imidazo[1,2-a]pyridin-7-yl]carbonyl]amino]ethyl]-4-(methylamino)pyridinium chloride
纯度： ≥98% (HPLC)
生物活性 for BAY 6096
BAY 6096 is a potent (IC50 = 14 nM), and selective adrenergic α2B receptor antagonist that displays 394, 725, >845-fold selectivity over α1A, α2A, and α2C, respectively. BAY 6096 reduces α2B receptor agonist-induced vasoconstriction and has a high clearance and low mean residence times in rats. BAY 6096 is highly water-soluble.
许可信息
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 6096 probe summary on the SGC website.
技术数据 for BAY 6096
| 分子量 | 426.91 |
| 公式 | C21H23ClN6O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2313483-41-7 |
| PubChem ID | 153534231 |
| InChI Key | HVVLGXULBVAFRZ-UHFFFAOYSA-N |
| Smiles | O=C(C1=CC2=NC=C(C3=C(C)ON=C3C)N2C=C1)NCC[N+]4=CC=C(NC)C=C4.[Cl-] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for BAY 6096
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 42.69 | 100 | |
| DMSO | 42.69 | 100 |
制备储备液 for BAY 6096
以下数据基于产品分子量 426.91。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.34 mL | 11.71 mL | 23.42 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.68 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.34 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
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产品说明书 for BAY 6096
参考文献 for BAY 6096
参考文献是支持产品生物活性的出版物。
Meibom et al (2023) BAY-6096: A potent, selective, and highly water-soluble adrenergic a2B antagonist. J Med Chem 66 4659 PMID: 36932954
If you know of a relevant reference for BAY 6096, please let us know.
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关键词: BAY 6096, BAY 6096 supplier, BAY6096, BAY-6096, Potent, selective, adrenergic, alpha2B, antagonists, in, vivo, α2B-adrenoceptor, adrenoceptors, α2b-adrenergic, alpha2b-adrenergic, a2b-adrenoceptor, receptors, Adrenergic, Alpha-2, Receptors, 8006, Tocris Bioscience
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