AR-C 102222

Name: AR-C 102222
Brand: Tocris Bioscience
SKU: 3969

Cat. No. 3969 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3969 has been discontinued.

View all iNOS products.

说明： Selective iNOS inhibitor

化学名： 5-[(4'-Amino-5',8'-difluorospiro[piperidine-4,2'(1'H)-quinaxolin]-1-yl)carbonyl]-2-pyridinecarbonitrile hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for AR-C 102222

AR-C 102222 is an inducible nitric oxide synthase (iNOS) inhibitor; selective for iNOS over eNOS (IC₅₀ values are 0.037 and >100 μM for iNOS and eNOS respectively). Exhibits antinociceptive and anti-inflammatory activity in rodent pain models.

许可信息

Sold with the permission of AstraZeneca UK Ltd.

技术数据 for AR-C 102222

分子量	418.83
公式	C₁₉H₁₆F₂N₆O.HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1781934-50-6
PubChem ID	21192822
InChI Key	FJFMOBYDHGJDGV-UHFFFAOYSA-N
Smiles	O=C(C4=CC=C(C#N)N=C4)N(CC3)CCC23N=C(N)C1=C(F)C=CC(F)=C1N2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for AR-C 102222

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AR-C 102222

参考文献是支持产品生物活性的出版物。

Tinker et al (2003) 1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo. J.Med.Chem. 46 913 PMID: 12620067

LaBuda et al (2006) Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and postoperative pain. Eur.J.Pain 10 505 PMID: 16125426

Bonnefous et al (2009) Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, Part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models. J.Med.Chem. 52 3047 PMID: 19374401

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关键词: AR-C 102222, AR-C 102222 supplier, AR-C102222, inhibits, inducible, nitric, oxide, synthase, iNOS, inhibitors, selective, astrazeneca, 3969, Tocris Bioscience

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