Antalarmin hydrochloride

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Cat.No. 2778 - Antalarmin hydrochloride | C24H34N4.HCl | CAS No. 220953-69-5
说明: CRF1 antagonist
化学名: N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride
纯度: ≥99% (HPLC)
引用文献 (4)
文献 (3)

生物活性 for Antalarmin hydrochloride

Antalarmin hydrochloride is a non-peptide corticotropin-releasing hormone receptor 1 (CRF1) antagonist (Ki = 1 nM). Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety.

化合物库 for Antalarmin hydrochloride

Antalarmin hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Antalarmin hydrochloride

分子量 415.01
公式 C24H34N4.HCl
储存 Desiccate at +4°C
纯度 ≥99% (HPLC)
CAS Number 220953-69-5
PubChem ID 16078945
Smiles CC1=C(C)N(C3=C(C)C=C(C)C=C3C)C2=C1C(N(CC)CCCC)=NC(C)=N2.Cl


Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Antalarmin hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
DMSO 41.5 100
ethanol 41.5 100

制备储备液 for Antalarmin hydrochloride

以下数据基于产品分子量 415.01。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.05 mL 24.1 mL
5 mM 0.48 mL 2.41 mL 4.82 mL
10 mM 0.24 mL 1.2 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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产品说明书 for Antalarmin hydrochloride


参考文献 for Antalarmin hydrochloride


Webster et al (1996) In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation. Endocrinology 137 5747 PMID: 8940412

Zorrilla et al (2002) Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. Brain Res. 952 188 PMID: 12376179

Specio et al (2008) CRF1 receptor antagonists attenuate escalated cocaine self-administration in rats. Psychopharmacol. 196 473 PMID: 17965976

If you know of a relevant reference for Antalarmin hydrochloride, please let us know.



查看全部 CRF1 Receptor Antagonists

关键词: Antalarmin hydrochloride, Antalarmin hydrochloride supplier, CRF1, antagonists, Corticotropin-Releasing, Factor1, Receptors, 2778, Tocris Bioscience

4 篇 Antalarmin hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Antalarmin hydrochloride 的部分引用包括:

Gray et al (2015) Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety. J Neurosci 35 3879 PMID: 25740517

Zhao-Shea et al (2015) Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Front Cell Neurosci 6 6770 PMID: 25898242

Narla et al (2015) Suppression of piriform cortex activity in rat by corticotropin-releasing factor 1 and serotonin 2A/C receptors. Psychoneuroendocrinology 9 200 PMID: 26074770

Wood et al (2006) Facilitation of cardiac vagal activity by CRF-R1 antagonists during swim stress in rats. Neuropsychopharmacology 31 2580 PMID: 16710322

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