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Submit ReviewA 71623
说明： Potent and selective CCK1agonist. Suppresses feeding
化学名： N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-methylphenyl)amino]carbonyl]-L-lysyl-L-a-aspartyl-Na-methyl-L-phenylalaninamide
生物活性 for A 71623
Potent CCK1 agonist (IC50 = 3.7 nM) with 1200-fold selectivity over the CCK2 receptor. Suppresses food intake following central or peripheral administration.
技术数据 for A 71623
| 分子量 | 840.97 |
| 公式 | C44H56N8O9 |
| 储存 | Desiccate at -20°C |
| CAS Number | 130408-77-4 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for A 71623
分析证书目前不在网上提供。
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参考文献 for A 71623
参考文献是支持产品生物活性的出版物。
Asin et al (1992) A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey. Pharmacol.Biochem.Behav. 42 699 PMID: 1513850
DeNinno et al (1990) Development of CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists. J.Med.Chem. 33 2951
Lin et al (1990) Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol.Pharmacol. 39 346
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关键词: A 71623, A 71623 supplier, A-71623, CCK, CCK1, CCK-1, Obesity, Feeding, Anorexia, Cholecystokinin, CCK-8, Receptor, 2036, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.