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Submit ReviewReported selective inhibitor of L-homocysteate uptake. Less active than the (2S,3S) isomer.
分子量 | 257.67 |
储存 | Store at RT |
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Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Chalmers et al (1995) Differential actions of 3-(4-chlorophenyl)glutamic acid stereoisomers and L-trans-pyrrolidine-2,4-dicarboxylic acid upon L-homocysteic acid and L-glutamic acid-induced responses from rat spinal motoneurones. Neuropharmacology 34 1589 PMID: 8788956
Jane et al (1996) Diastereoselective synthesis of all four isomers of 3-(4-chlorophenylglutamic acid: identification of the isomers responsible for the potentiation of L-homocysteic acid-evoked depolarizations in neonatal rat motoneurons. J.Med.Chem. 39 4738 PMID: 8941386
关键词: (2S,3R)-Chlorpheg, (2S,3R)-Chlorpheg supplier, Glutamate, Transporters, 0818, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.