WEB 2086

Pricing Availability   Qty
Cat.No. 2339 - WEB 2086 | C22H22N5O2SCl | CAS No. 105219-56-5
说明: Potent PAF receptor antagonist
别名: Apafant
化学名: 4-[3-[4[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]diazepin-2-yl]-1-oxopropyl]morpholine
纯度: ≥99% (HPLC)
说明书
引用文献 (6)
评论
文献 (3)

生物活性 for WEB 2086

WEB 2086 is a potent, selective platelet-activating factor (PAF) receptor antagonist (Ki = 16.3 nM). Displays anti-inflammatory, antiangiogenic and anticancer activity. Inhibits growth and proliferation of MCF-7 breast cancer cells.

化合物库 for WEB 2086

WEB 2086 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for WEB 2086

分子量 455.96
公式 C22H22N5O2SCl
储存 Desiccate at +4°C
纯度 ≥99% (HPLC)
CAS Number 105219-56-5
PubChem ID 65889
InChI Key JGPJQFOROWSRRS-UHFFFAOYSA-N
Smiles CC1=NN=C2CN=C(C3=C(SC(CCC(=O)N4CCOCC4)=C3)N12)C1=CC=CC=C1Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WEB 2086

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 45.6 100
ethanol 45.6 100 温和加热

制备储备液 for WEB 2086

以下数据基于产品分子量 455.96。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.97 mL 21.93 mL
5 mM 0.44 mL 2.19 mL 4.39 mL
10 mM 0.22 mL 1.1 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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产品说明书 for WEB 2086

分析证书/产品说明书
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参考文献 for WEB 2086

参考文献是支持产品生物活性的出版物。

Dent et al (1989) Characterization of PAF receptors on human neutrophils using the specific antagonist, WEB 2086. FEBS Lett. 244 365 PMID: 2537761

Sariahmetoglu et al (1998) Effects of WEB 2086 on the protective role of preconditioning against arrhythmias in rats. Pharmacol.Res. 38 173 PMID: 9782066

Cellai et al (2006) Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086. Br.J.Cancer 94 1637 PMID: 16721373


If you know of a relevant reference for WEB 2086, please let us know.

按标靶查看相关产品

关键词: WEB 2086, WEB 2086 supplier, Potent, PAF, receptor, antagonists, Receptors, Platelet-activating, Factor, WEB2086, Apafant, (PAF), 2339, Tocris Bioscience

6 篇 WEB 2086 的引用文献

引用文献是使用了 Tocris 产品的出版物。 WEB 2086 的部分引用包括:

Al-Shawaf et al (2010) Short-term stimulation of calcium-permeable transient receptor potential canonical 5-containing channels by oxidized phospholipids. Arterioscler Thromb Vasc Biol 30 1453 PMID: 20378846

Zhao et al (2013) Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice. Br J Pharmacol 8 e82683 PMID: 24367540

Yagnik (2014) Macrophage derived platelet activating factor implicated in the resolution phase of gouty inflammation. Int J Inflam 2014 526496 PMID: 25328755

Wu et al (2014) Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. PLoS One 9 e93003 PMID: 24671173


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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。


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