WAY 200070

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Cat.No. 3366 - WAY 200070 | C13H8BrNO3 | CAS No. 440122-66-7
说明: Selective ERβ agonist
化学名: 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
纯度: ≥98% (HPLC)
引用文献 (4)
文献 (2)
通路 (1)

生物活性 for WAY 200070

WAY 200070 is a selective ERβ receptor agonist that displays 68-fold selectivity over ERα (EC50 values are 2 and 155 nM for ERβ and ERα respectively). Displays antianxiolytic and antidepressive effects in vivo.

化合物库 for WAY 200070

WAY 200070 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for WAY 200070

分子量 306.11
公式 C13H8BrNO3
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 440122-66-7
PubChem ID 9861330
Smiles BrC1=C2C(N=C(C3=CC=C(O)C=C3)O2)=CC(O)=C1


Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WAY 200070

溶剂 最高浓度 mg/mL 最高浓度 mM
DMSO 30.61 100
ethanol 15.31 50

制备储备液 for WAY 200070

以下数据基于产品分子量 306.11。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.27 mL 16.33 mL 32.67 mL
5 mM 0.65 mL 3.27 mL 6.53 mL
10 mM 0.33 mL 1.63 mL 3.27 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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参考文献 for WAY 200070


Malamas et al (2004) Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands. J.Med.Chem. 47 5021 PMID: 15456246

Hughes et al (2008) WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent. Neuropharmacology 54 1136 PMID: 18423777

Clipperton et al (2008) Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice. Neuropsychopharmacology 33 2362 PMID: 18004284

If you know of a relevant reference for WAY 200070, please let us know.



查看全部 Estrogen and Related Receptor Agonists

关键词: WAY 200070, WAY 200070 supplier, Selective, ERβ, ERbeta, agonists, estrogen, receptors, WAY200070, Estrogen, and, Related, Receptors, 3366, Tocris Bioscience

4 篇 WAY 200070 的引用文献

引用文献是使用了 Tocris 产品的出版物。 WAY 200070 的部分引用包括:

Cao et al (2012) Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat. J Pain 13 685 PMID: 22698981

Sellers et al (2015) Rapid modulation of synaptogenesis and spinogenesis by 17β-OE in primary cortical neurons. Front Cell Neurosci 9 137 PMID: 25926772

Alonso-Magdalena et al (2013) Antidiabetic actions of an estrogen receptor β selective agonist. PLoS One 62 2015 PMID: 23349481

Oberlander (2016) 17β-OE Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females. J Neurosci 36 2677 PMID: 26937008

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Pathways for WAY 200070


Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.