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说明： High affinity CBX4 and CBX7 inhibitor
化学名： N-[4-(1,1-Dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-serine methyl ester
生物活性 for UNC 3866
High affinity CBX4 and CBX7 inhibitor (Ki values are 94 and 97 nM, respectively). Exhibits >6-fold selectivity for CBX4/7 over other CBX and CDY family members. Inhibits proliferation of PC3 cells in vitro.
External Portal Information for UNC 3866
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of UNC 3866 is reviewed on the chemical probes website.
技术数据 for UNC 3866
| 分子量 | 795.02 |
| 公式 | C43H66N6O8 |
| 储存 | Store at -20°C |
| CAS Number | 1872382-47-2 |
| PubChem ID | 101043861 |
| InChI Key | UMRRDXVUROEIKJ-JCXBGQGISA-N |
| Smiles | CCN(CCCC[C@@H](C(N[C@H](C(OC)=O)CO)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(C1=CC=C(C(C)(C)C)C=C1)=O)CC2=CC=CC=C2)=O)C)=O)CC(C)C)=O)CC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for UNC 3866
参考文献 for UNC 3866
参考文献是支持产品生物活性的出版物。
Stuckey et al (2016) A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat.Chem.Biol. 12 180 PMID: 26807715
Barnash et al (2016) Chromodomain ligand optimization via target-class directed combinatorial repurposing. ACS Chem.Biol. 11 2475 PMID: 27356154
Stuckey et al (2016) Structure-activity relationships and kinetic studies of peptidic antagonists of CBX chromodomains. J.Med.Chem. 59 8913 PMID: 27571219
关键词: UNC 3866, UNC 3866 supplier, UNC3866, high, affinity, CBX4, CBX7, inhibitors, Other, Lysine, Methyltransferases, 6096, Tocris Bioscience
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