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Submit ReviewUNC 2327
Discontinued Product
5057 has been discontinued.
View all Protein Arginine Methyltransferases products.
说明： Allosteric inhibitor of PRMT3
化学名： N-1,2,3-Benzothiadiazol-6-yl-N'-[2-oxo-2-(1-piperidinyl)ethyl]urea
纯度： ≥99% (HPLC)
生物活性 for UNC 2327
UNC 2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 230 nM). Noncompetitive with both the peptide substrate and cofactor.
化合物库 for UNC 2327
UNC 2327 is also offered as part of the Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。
技术数据 for UNC 2327
| 分子量 | 319.38 |
| 公式 | C14H17N5O2S |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1426152-53-5 |
| PubChem ID | 71583615 |
| InChI Key | MYTRGTBDVGKKRO-UHFFFAOYSA-N |
| Smiles | O=C(NCC(N3CCCCC3)=O)NC1=CC=C(N=NS2)C2=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for UNC 2327
参考文献 for UNC 2327
参考文献是支持产品生物活性的出版物。
Liu et al (2013) Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. J.Med.Chem. 56 2110 PMID: 23445220
关键词: UNC 2327, UNC 2327 supplier, UNC2327, Allosteric, inhibitors, inhibits, protein, arginine, methyltransferases, 3, PRMT3, Protein, Arginine, Methyltransferases, 5057, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.