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Submit ReviewU 83836E
说明： Antioxidant; inhibits lipid peroxidation
别名： PNU 83836E
化学名： (2R)-2-[[4-(2,6-Di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]methyl]-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol dihydrochloride
纯度： ≥98% (HPLC)
生物活性 for U 83836E
Free radical scavenger and antioxidant; second generation lazaroid that inhibits iron-dependent lipid peroxidation (IC50 = 1.5 μM). Displays neuroprotective activity in a mouse head injury model (MHI) and causes a reduction in cyanide-induced cell death in rat cortical neurons.
技术数据 for U 83836E
| 分子量 | 593.63 |
| 公式 | C30H44N6O2.2HCl |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 137018-55-4 |
| Smiles | OC1=C(C)C(C)=C(O[C@](CN3CCN(C4=CC(N6CCCC6)=NC(N5CCCC5)=N4)CC3)(C)CC2)C2=C1C.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for U 83836E
参考文献 for U 83836E
参考文献是支持产品生物活性的出版物。
Jacobsen et al (1992) 2-(aminomethyl)chromans that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma and ischemia. J.Med.Chem. 35 4464 PMID: 1447746
Altavilla et al (1998) Inhibition of tumour necrosis factor and reversal of endotoxin-induced shock by U-83836E, a 'second generation' lazaroid in rats. Br.J.Pharmacol. 124 1293 PMID: 9720803
Vignes and Hugon (2006) In vitro efficacy of three lazaroids in a model of acute chemical neuronal hypoxia. Neurosci.Lett. 407 171 PMID: 16973271
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关键词: U 82836E, U 82836E supplier, Antioxidant, inhibits, inhibitors, lipid, peroxidation, U82836E, PNU83836E, PNU, 83836E, Antioxidants, 2750, Tocris Bioscience
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