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说明： Potent soluble epoxide hydrolase inhibitor; orally bioavailable and brain penetrant
化学名： N-[1-(1-Oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]urea
纯度： ≥98% (HPLC)
生物活性 for TPPU
TPPU is a potent soluble epoxide hydrolase (sEH) inhibitor (IC50 values are 1.1 and 2.1 nM for murine and human receptor, respectively). Inhibits MAPK and NF-κB signaling, as well as reducing ER stress and cell death in models of pancreatitis. Exhibits antidepressant effects in a social defeat stress model. Orally bioavailable and brain penetrant.
技术数据 for TPPU
| 分子量 | 359.34 |
| 公式 | C16H20F3N3O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1222780-33-7 |
| PubChem ID | 44142782 |
| InChI Key | AAJMQTLFRTZCJK-UHFFFAOYSA-N |
| Smiles | CCC(N1CCC(NC(NC2=CC=C(C=C2)OC(F)(F)F)=O)CC1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TPPU
参考文献 for TPPU
参考文献是支持产品生物活性的出版物。
Ren et al (2016) Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proc.Natl.Acad.Sci.U.S.A. 113 E1944 PMID: 26976569
Bettaieb et al (2015) Soluble epoxide hydrolase pharmacological inhibition ameliorates experimental acute pancreatitis in mice. Mol.Pharmacol. 88 281 PMID: 25993999
Rose et al (2010) 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. J.Med.Chem. 53 7067 PMID: 20812725
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关键词: TPPU, TPPU supplier, potent, soluble, epoxide, hydrolase, inhibitors, inhibits, brain, penetrant, orally, bioavailable, antidepressant, anti-inflammatory, Other, Hydrolases, 5918, Tocris Bioscience
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