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Submit ReviewTCN 237 dihydrochloride
说明： Highly potent and selective GluN2B NMDA antagonist
化学名： 2-[[4-[(2-Fluorophenyl)methyl]-1-piperidinyl]methyl]-1H-benzimidazol-6-ol dihydrochloride
纯度： ≥98% (HPLC)
生物活性 for TCN 237 dihydrochloride
TCN 237 dihydrochloride is a highly potent GluN2B (formally NR2B) selective NMDA receptor antagonist (Ki = 0.8 nM); blocks GluN2B-mediated calcium influx in Ltk cells (Ki = 9.7 nM). Selective for GluN2B subunit over α1-adrenergic receptors and hERG channels (IC50 values are 730 nM and 2900 nM respectively). Displays efficacy in the rat carrageenan-induced mechanical hyperalgesia assay.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
技术数据 for TCN 237 dihydrochloride
| 分子量 | 412.33 |
| 公式 | C20H22FN3O.2HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 700878-19-9 |
| PubChem ID | 90488908 |
| InChI Key | JYUWGWCFJMDMND-UHFFFAOYSA-N |
| Smiles | FC1=CC=CC=C1CC(CC4)CCN4CC3=NC2=CC=C(O)C=C2N3.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TCN 237 dihydrochloride
参考文献 for TCN 237 dihydrochloride
参考文献是支持产品生物活性的出版物。
McCauley et al (2004) NR2B-selective N-MthD.-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J.Med.Chem. 47 2089 PMID: 15056006
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