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Submit ReviewTCN 213
说明： NMDA antagonist; selective for GluN2A over GluN2B containing receptors
化学名： N-(Cyclohexylmethyl)-2-[(5-[(phenylmethyl)amino]-1,3,4-thiadiazol-2-yl}thio]acetamide
纯度： ≥99% (HPLC)
生物活性 for TCN 213
TCN 213 is a NMDA receptor antagonist, selective for GluN1/GluN2A (formally NR1/NR2A) (pIC50 = 5.4) over GluN1/GluN2B (formally NR1/NR2B) containing receptors.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
技术数据 for TCN 213
| 分子量 | 376.54 |
| 公式 | C18H24N4OS2 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 556803-08-8 |
| PubChem ID | 2608149 |
| InChI Key | XBAZPYFIYYCZBO-UHFFFAOYSA-N |
| Smiles | O=C(NCC2CCCCC2)CSC1=NN=C(NCC3=CC=CC=C3)S1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TCN 213
参考文献 for TCN 213
参考文献是支持产品生物活性的出版物。
Bettini et al (2010) Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors. J.Pharmacol.Exp.Ther. 335 644 PMID: 20810618
McKay et al (2012) Direct pharmacological monitoring of the developmental switch in NMDAR subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist. Br.J.Pharmacol. 166 924 PMID: 22022974
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关键词: TCN 213, TCN 213 supplier, TCN213, selective, NMDA, receptor, antagonist, NR1/NR2A, NR2A-containing, NR2B, GluN1, GluN2A, GluN2B, Receptors, 4163, Tocris Bioscience
3 篇 TCN 213 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TCN 213 的部分引用包括：
Izumi and Zorumski (2015) Sensitivity of N-MthD.-aspartate receptor-mediated excitatory postsynaptic potentials and synaptic plasticity to TCN 201 and TCN 213 in rat hippocampal slices. Int J Mol Sci 352 267 PMID: 25413830
Prickett et al (2014) Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation. J Invest Dermatol 134 2390 PMID: 24739903
McKay et al (2012) Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist. Br J Pharmacol 166 924 PMID: 22022974
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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