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TC-G 1006

Cat. No. 4747 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4747 has been discontinued.

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说明： Potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist
化学名： 4-Methoxy-N-[[[2-trifluoromethyl)[1,1'-biphenyl]-4-yl]amino]carbonyl]-3-pyridinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for TC-G 1006

TC-G 1006 is a potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 35 nM), displays >100-fold selectivity against receptor subtypes S1P2-5. Induces a dose-dependent reduction in circulating blood lymphocyte counts in rodent models. Orally bioavailable.

技术数据 for TC-G 1006

分子量 415.37
公式 C21H16F3N3O3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1324003-64-6
PubChem ID 54764919
InChI Key MLDQTQOMWDNTNN-UHFFFAOYSA-N
Smiles O=C(NC(C2=C(OC)C=CN=C2)=O)NC1=CC=C(C3=CC=CC=C3)C(C(F)(F)F)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for TC-G 1006

参考文献是支持产品生物活性的出版物。

Pennington et al (2011) 4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1. ACS Med.Chem.Lett. 2 752 PMID: 24900263

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关键词: TC-G 1006, TC-G 1006 supplier, TC-G1006, Sphingosine-1-phosphate, receptor, 1, agonists, Receptors, 4747, Tocris Bioscience

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