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Submit ReviewTalsupram hydrochloride is a selective noradrenalin re-uptake inhibitor; exhibits a high affinity for the human noradrenalin transporter (NET) against SERT and DAT (IC50 values are 0.79, 850 and 9300 nM for inhibition of monoamine uptake by NET, SERT and DAT respectively). Antidepressant.
分子量 | 347.95 |
公式 | C20H25NS.HCl |
储存 | Desiccate at RT |
纯度 | ≥98% (HPLC) |
CAS Number | 25487-28-9 |
PubChem ID | 33013 |
InChI Key | YMZCMCDSCRSIBS-UHFFFAOYSA-N |
Smiles | CC2(C)SC(C3=CC=CC=C3)(CCCNC)C1=CC=CC=C12.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
McConathy et al (2004) Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the NE transporter. Nucl.Med.Biol. 31 705 PMID: 15246361
Schou et al (2006) Synthesis and positron emission tomography evaluation of three NE transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram. Mol.Imaging Biol. 8 1
Rowlett et al (2004) Cocaine-like discriminative stimulus effects of heroin: modulation by selective monoamine transport inhibitors. J.Pharmacol.Exp.Ther. 310 342 PMID: 14985417
关键词: Talsupram hydrochloride, Talsupram hydrochloride supplier, norepinephrine, reuptake, inhibitors, inhibits, noradrenaline, noradrenalin, transporters, NET, antidepressants, selective, Adrenergic, Transporters, 4352, Tocris Bioscience
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