SU 11274

Name: SU 11274
Brand: Tocris Bioscience
SKU: 4101

Cat. No. 4101 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4101 has been discontinued.

View all MET Receptors products.

说明： Selective inhibitor of MET kinase activity

化学名： (3Z)-N-(3-Chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide

纯度： ≥97% (HPLC)

说明书

引用文献 (5)

生物活性技术数据说明书参考文献

生物活性 for SU 11274

Selective inhibitor of MET tyrosine kinase activity (IC₅₀ = 0.01 μM in vitro). Reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migration in vitro and tumor angiogenesis in vivo.

技术数据 for SU 11274

分子量	568.09
公式	C₂₈H₃₀ClN₅O₄S
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	658084-23-2
PubChem ID	9549297
InChI Key	FPYJSJDOHRDAMT-KQWNVCNZSA-N
Smiles	CC1=C(\C=C(C3=CC(S(N(C)C5=CC(Cl)=CC=C5)(=O)=O)=CC=C3N4)/C4=O)NC(C)=C1C(N2CCN(C)CC2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for SU 11274

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SU 11274

参考文献是支持产品生物活性的出版物。

Sattler et al (2003) A novel small molecule Met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. Cancer Res. 63 5462 PMID: 14500382

Wang et al (2003) Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth. Mol.Cancer Ther. 2 1085 PMID: 14617781

Seiwert et al (2009) The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res. 69 3021 PMID: 19318576

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关键词: SU 11274, SU 11274 supplier, SU11274, Supplier, c-Met, inhibitors, inhibits, MET, tyrosine, kinase, activity, met, receptors, Receptors, 4101, Tocris Bioscience