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Submit ReviewSR 202
说明： Selective PPARγ antagonist; antidiabetic and antiobesity agent
别名： Mifobate
化学名： (4-Chlorophenyl)(dimethoxyphosphinyl)methyl phosphoric acid dimethyl ester
纯度： ≥99% (HPLC)
生物活性 for SR 202
SR 202 is a selective PPARγ antagonist; antidiabetic and antiobesity agent. Attenuates troglitazone-induced PPARγ transcriptional activity (IC50 = 140 μM) without affecting ligand-stimulated PPARα, PPARβ or FXR transcriptional activity. Inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo. Improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo.
技术数据 for SR 202
| 分子量 | 358.65 |
| 公式 | C11H17ClO7P2 |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 76541-72-5 |
| PubChem ID | 60910 |
| InChI Key | VQHUQHAPWMNBLP-UHFFFAOYSA-N |
| Smiles | COP(=O)(OC)OC(C1=CC=C(Cl)C=C1)P(=O)(OC)OC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SR 202
参考文献 for SR 202
参考文献是支持产品生物活性的出版物。
Nguyen et al (1987) gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity. J.Med.Chem. 30 1426 PMID: 3612689
Rieusset et al (2002) A new selective peroxisome proliferator-activated receptor γ antagonist with antiobesity and antidiabetic activity. Mol.Endocrinol. 16 2628 PMID: 12403851
Doggrell (2003) Do peroxisome proliferation receptor-γ antagonists have clinical potential as combined antiobesity and antidiabetic drugs? Expert.Opin.Invest.Drugs 12 713
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关键词: SR 202, SR 202 supplier, Selective, PPARγ, PPARgamma, antagonists, antidiabetic, antiobesity, agent, Peroxisome, Proliferator-activating, Receptors, SR202, Mifobate, 2022, Tocris Bioscience
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