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SLV 320

Cat. No. 3344 2 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3344 has been discontinued.

View all Adenosine A<sub>1</sub> Receptors products.
说明： Potent and selective A1 antagonist
化学名： trans-4-[(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for SLV 320

SLV 320 is a potent and selective adenosine A1 receptor antagonist (Ki values are 1, 200, 398 and 3981 nM at human A1, A3, A2A and A2B receptors respectively). Suppresses cardiac fibrosis and attenuates albuminuria, without effect on blood pressure in animal models of chronic renal failure. Orally active.

技术数据 for SLV 320

分子量 308.38
公式 C18H20N4O
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 251945-92-3
PubChem ID 9953065
InChI Key RBZNJGHIKXAKQE-UHFFFAOYSA-N
Smiles O[C@@H](CC4)CC[C@H]4NC1=C2C(NC=C2)=NC(C3=CC=CC=C3)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for SLV 320

参考文献是支持产品生物活性的出版物。

Kalk et al (2007) The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without effecting blood pressure. Br.J.Pharmacol. 151 1025 PMID: 17558436

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关键词: SLV 320, SLV 320 supplier, Potent, selective, A1, antagonists, Receptors, adenosines, SLV320, Adenosine, 3344, Tocris Bioscience

2 篇 SLV 320 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SLV 320 的部分引用包括：

Cheng et al (2017) Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity. Structure 25 1275 PMID: 28712806

Badders (2018) Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbarmuscular atrophy. Nat Med 24 424 PMID: 29505030

SLV 320 的评论

平均评分: 5 (Based on 1 Review.)

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SLV320 to inhibit adenosine A1 receptor in piglet afferent arteriole.
By Hitesh Soni on 01/04/2018
分析类型： In Vitro
种属： Pig
细胞系/组织： Renal Afferent Arteriole

To inhibit adenosine A1 receptor in isolated pig afferent arteriole from kidney. We have performed calcium imaging study using this compound. We have also used pyr3 from Tocris and published results in AJP-renal journal recently. American Journal of Physiology-Renal Physiology 313 (6), F1216-F1222

PMID: 28855189
review image