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Submit ReviewSKI 178
说明： Non-lipid sphingosine kinase 1 (SphK1) inhibitor
化学名： N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide
纯度： ≥98% (HPLC)
生物活性 for SKI 178
Non-lipid sphingosine kinase 1 (SphK1) inhibitor (IC50 = 0.1-1.8 μM). Induces CDK1-dependent apoptosis in human acute myeloid leukemia cell lines. Active in vivo.
技术数据 for SKI 178
| 分子量 | 394.42 |
| 公式 | C21H22N4O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1259484-97-3 |
| PubChem ID | 5342941 |
| InChI Key | GMFUWEBOUKIKRP-LPYMAVHISA-N |
| Smiles | O=C(N/N=C(C)/C1=CC=C(OC)C(OC)=C1)C2=CC(C3=CC=C(OC)C=C3)=NN2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SKI 178
参考文献 for SKI 178
参考文献是支持产品生物活性的出版物。
Dick et al (2015) The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines. J.Pharmacol.Exp.Ther. 352 494 PMID: 25563902
Hengst et al (2010) Development of a sphingosine kinase 1 specific small-molecule inhibitor. Bioorg.Med.Chem.Lett. 20 7498 PMID: 21050755
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关键词: SKI 178, SKI 178 supplier, SKI178, Inhibitors, Inhibits, Sphingosine, kinase, 1, SphK1, Kinase, 5452, Tocris Bioscience
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