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SK1-I

Cat. No. 3711 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3711 has been discontinued.

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说明： Sphingosine kinase 1 (SphK1) inhibitor; antiproliferative
化学名： 1,2,4-Trideoxy-4-(methylamino)-1-(4-pentylphenyl)-D-erythro-pent-1-enitol hydrochloride
纯度： ≥98% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for SK1-I

Sphingosine kinase (SphK) inhibitor. Isoenzyme-selective for SphK1; displays no activity at SphK2. Also displays no inhibitory activity against a range of protein kinases including PKC, PKA, ERK1, EGFR and CDK2. Exhibits potent antileukemic activity in vivo; inhibits the growth of both U937 and Jurkat T cells. Also suppresses proliferation and induces apoptosis in several human glioblastoma cell lines.

技术数据 for SK1-I

分子量 313.86
公式 C17H27NO2.HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1072443-89-0
Smiles CCCCCC1=CC=C(/C=C/[C@H](O)[C@H](NC)CO)C=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for SK1-I

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参考文献 for SK1-I

参考文献是支持产品生物活性的出版物。

Kapitonov et al (2009) Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. Cancer Res. 69 6915 PMID: 19723667

Paugh et al (2009) Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells. J.Biol.Chem. 284 3408 PMID: 19074142

Paugh et al (2008) A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Neoplasia 112 1382

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关键词: SK1-I, SK1-I supplier, sphingosine-1-phosphate, kinases, sphk1, inhibitors, inhibits, proapoptotic, antiproliferative, Sphingosine, Kinase, Other, Lipid, Metabolism, 3711, Tocris Bioscience

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