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Submit ReviewSC 51322
说明： Potent EP1 receptor antagonist
化学名： 8-Chloro-2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]-dibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylic acid hydrazide
纯度： ≥98% (HPLC)
生物活性 for SC 51322
SC 51322 is a potent EP1 prostanoid receptor antagonist (Ki = 13.8 nM). Displays analgesic properties in vivo.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
化合物库 for SC 51322
SC 51322 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for SC 51322
| 分子量 | 457.93 |
| 公式 | C22H20ClN3O4S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 146032-79-3 |
| PubChem ID | 9933831 |
| InChI Key | CQBVTZDISUKDSX-UHFFFAOYSA-N |
| Smiles | O=C(NNC(CCSCC4=CC=CO4)=O)N3CC1=CC=CC=C1OC2=CC=C(Cl)C=C23 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SC 51322
参考文献 for SC 51322
参考文献是支持产品生物活性的出版物。
Durocher et al (2000) A reporter gene assay for high-throughput screening of G-protein-coupled receptors stably or transiently expressed in HEK293 EBNA cells grown in suspension culture Anal.Biochem. 284 316 PMID: 10964415
Hallinan et al (1994) 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid,2-[3-[2-(furanylmethyl)thio]-1-oxopropyl]hydrazide (SC-51322): A potent PGE2 antagonist and analgesic. Bioorg.Med.Chem.Lett. 4 509
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关键词: SC 51322, SC 51322 supplier, potent, prostanoids, EP1, receptors, antagonists, PGE2, prostaglandins, prostacyclins, eicosanoids, SC51322, Pfizer, Prostanoid, Receptors, 2791, Tocris Bioscience
1 篇 SC 51322 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SC 51322 的部分引用包括：
Guillem-Llobat et al (2016) Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells. Oncotarget 7 32462 PMID: 27074574
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