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RMM 46

Cat. No. 5909 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5909 has been discontinued.

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说明： MSK/RSK family kinase inhibitor
化学名： 2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for RMM 46

RMM 46 is a MSK/RSK family kinase inhibitor. Exhibits selectivity for RSK2 over NEK2 and PLK1 (IC50s are 12, 530 and 2200 nM, respectively). Inhibits MSK1, MSK2, RSK2 and RSK3 in cellular assays. Reduces CREB phosphorylation in HeLa cells.

技术数据 for RMM 46

分子量 450.5
公式 C24H26N4O5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1307896-46-3
PubChem ID 67206797
InChI Key FCCMYBKAZCDQGX-LZYBPNLTSA-N
Smiles [H]/C(C1=CC=C(NN=C2C3=CC(OC)=C(OC)C(OC)=C3)C2=C1)=C(C#N)\C(NC(C)(C)CO)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for RMM 46

参考文献是支持产品生物活性的出版物。

Miller et al (2013) Electrophilic fragment-based design of reversible covalent kinase inhibitors. J.Am.Chem.Soc. 135 5298 PMID: 23540679

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关键词: RMM 46, RMM 46 supplier, RMM46, RSK2, 3, MSK1, inhibitors, inhibits, family, kinases, CREB, phosphorylation, RSK, 5909, Tocris Bioscience

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