PSB 36

Pricing Availability   Qty
Cat.No. 2019 - PSB 36 | C21H30N4O3 | CAS No. 524944-72-7
说明: Potent and selective A1 antagonist
化学名: 1-Butyl-8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-3-(3-hydroxypropyl)-1H-purine-2,6-dione
纯度: ≥99% (HPLC)
说明书
引用文献 (5)
评论
文献 (4)

生物活性 for PSB 36

PSB 36 is a potent and selective A1 adenosine receptor antagonist. Displays binding affinities of 0.12, 187, 552, 6500 and 2300 nM for rA1, hA2B, rA2A, rA3 and hA3 receptors respectively. Demonstrates greater selectivity than DPCPX (Cat. No. 0439).

化合物库 for PSB 36

PSB 36 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PSB 36

分子量 386.49
公式 C21H30N4O3
储存 Desiccate at +4°C
纯度 ≥99% (HPLC)
CAS Number 524944-72-7
PubChem ID 11689583
InChI Key CIBIXJYFYPFMTN-UHFFFAOYSA-N
Smiles CCCCN1C(=O)N(CCCO)C2=C(NC(=N2)C23CC4CC2CC(C3)C4)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PSB 36

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 38.65 100
ethanol 38.65 100

制备储备液 for PSB 36

以下数据基于产品分子量 386.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.59 mL 12.94 mL 25.87 mL
5 mM 0.52 mL 2.59 mL 5.17 mL
10 mM 0.26 mL 1.29 mL 2.59 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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参考文献 for PSB 36

参考文献是支持产品生物活性的出版物。

Abo-Salem et al (2004) Antinociceptive effects of novel A2B adenosine receptor antagonists. J.Pharmacol.Exp.Ther 308 358 PMID: 14563788

Weyler et al (2006) Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones. Chem.Med.Chem. 1 891


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查看全部 Adenosine A1 Receptor Antagonists

关键词: PSB 36, PSB 36 supplier, Potent, selective, A1, antagonists, Receptors, adenosines, PSB36, Adenosine, 2019, Tocris Bioscience

5 篇 PSB 36 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PSB 36 的部分引用包括:

Ziemlinska et al (2014) Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats. PLoS One 9 e88833 PMID: 24551172

Carlström et al (2010) Adenosine A(2) receptors modulate tubuloglomerular feedback. Am J Physiol Renal Physiol 299 F412 PMID: 20519378

Guerreiro et al (2008) Paraxanthine, the primary metabolite of caffeine, provides protection against DArgic cell death via stimulation of ryanodine receptor channels. Mol Pharmacol 74 980 PMID: 18621927

Cheng et al (2017) Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity. Structure 25 1275 PMID: 28712806


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