PSB 36

停产产品

PSB 36(目录编号 @cat_num)因商业原因已下架.
Cat.No. 2019 - PSB 36 | C21H30N4O3 | CAS No. 524944-72-7
说明: Potent and selective A1 antagonist
化学名: 1-Butyl-8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-3-(3-hydroxypropyl)-1H-purine-2,6-dione
纯度: ≥99% (HPLC)
说明书
引用文献 (6)
评论
文献 (4)

生物活性 for PSB 36

PSB 36 is a potent and selective A1 adenosine receptor antagonist. PSB 36 displays binding affinities of 0.12, 187, 552, 6500 and 2300 nM for rA1, hA2B, rA2A, rA3 and hA3 receptors respectively. PSB 36 demonstrates greater selectivity than DPCPX (Cat. No. 0439). PSB 36 reduces atrial fibrillation in rat isolated beating heart preparations.

技术数据 for PSB 36

分子量 386.49
公式 C21H30N4O3
储存 Desiccate at +4°C
纯度 ≥99% (HPLC)
CAS Number 524944-72-7
PubChem ID 11689583
InChI Key CIBIXJYFYPFMTN-UHFFFAOYSA-N
Smiles CCCCN1C(=O)N(CCCO)C2=C(NC(=N2)C23CC4CC2CC(C3)C4)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for PSB 36

参考文献是支持产品生物活性的出版物。

Abo-Salem et al (2004) Antinociceptive effects of novel A2B adenosine receptor antagonists. J.Pharmacol.Exp.Ther 308 358 PMID: 14563788

Weyler et al (2006) Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones. Chem.Med.Chem. 1 891

Soattin et al (2020) Inhibition of adenosine pathway alters atrial electrophysiology and prevents atrial fibrillation. Front Physiol. 11 493 PMID: 32595514

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Adenosine A1 Receptor Antagonists

关键词: PSB 36, PSB 36 supplier, Potent, selective, A1, antagonists, Receptors, adenosines, PSB36, Adenosine, 2019, Tocris Bioscience

6 篇 PSB 36 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PSB 36 的部分引用包括:

Carlström et al (2010) Adenosine A(2) receptors modulate tubuloglomerular feedback. Am J Physiol Renal Physiol 299 F412 PMID: 20519378

Soattin et al (2020) Inhibition of adenosine pathway alters atrial electrophysiology and prevents atrial fibrillation. Front Physiol. 11 493 PMID: 32595514

Arnal et al (2013) Influence of age, body temperature, GABAA receptor inhibition and caffeine on the Hering-Breuer inflation reflex in unanesthetized rat pups. Respir Physiol Neurobiol 186 73 PMID: 23318703

Cheng et al (2017) Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity. Structure 25 1275 PMID: 28712806


PSB 36 的评论

目前没有该产品的评论。 Be the first to review PSB 36 and earn rewards!

Have you used PSB 36?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。


Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Pain Research Product Guide

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Cardiovascular Poster

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.