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说明： Potent, selective PPARγ partial agonist
化学名： 5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid
纯度： ≥98% (HPLC)
生物活性 for nTZDpa
nTZDpa is a potent, selective non-thiazolidinedione PPARγ partial agonist (EC50 = 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC50 ~ 285 nM). Displays no activity at PPARα or PPARδ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPARγ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo.
技术数据 for nTZDpa
| 分子量 | 428.33 |
| 公式 | C22H15Cl2NO2S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 118414-59-8 |
| PubChem ID | 9954280 |
| InChI Key | VUPOTURDKDMIGQ-UHFFFAOYSA-N |
| Smiles | OC(=O)C1=C(SC2=CC=CC=C2)C2=CC(Cl)=CC=C2N1CC1=CC=C(Cl)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for nTZDpa
参考文献 for nTZDpa
参考文献是支持产品生物活性的出版物。
Berger et al (2003) Distinct properties and advantages of a novel peroxisome proliferator-activated protein γ selective modulator. Mol.Endocrinol. 17 662 PMID: 12554792
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关键词: nTZDpa, nTZDpa supplier, Potent, selective, PPARγ, PPARgamma, partial, agonists, Peroxisome, Proliferator-activating, Receptors, 2150, Tocris Bioscience
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