NPC 15437 dihydrochloride

Name: NPC 15437 dihydrochloride
Brand: Tocris Bioscience
SKU: 1628

Cat. No. 1628 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1628 has been discontinued.

View all Protein Kinase C products.

说明： Selective protein kinase C inhibitor

化学名： (2S)-2,6-Diamino-N-[[1-(1-oxotridecyl)-2-piperidinyl]methyl]hexanamide dihydrochloride

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for NPC 15437 dihydrochloride

Highly selective, competitive and reversible inhibitor of protein kinase C (IC₅₀ = 19 mM); interacts at the regulatory domain of the enzyme. May modulate P-glycoprotein in tumor cells in vitro via inhibiton of PKC. Centrally active following systemic administration in vivo.

技术数据 for NPC 15437 dihydrochloride

分子量	511.62
公式	C₂₅H₅₀N₄O₂.2HCl
储存	Desiccate at +4°C
CAS Number	136449-85-9
Smiles	O=C(CCCCCCCCCCCC)N1C(CNC([C@H](CCCCN)N)=O)CCCC1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for NPC 15437 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NPC 15437 dihydrochloride

参考文献是支持产品生物活性的出版物。

Mathis et al (1992) The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice. Eur.J.Pharmacol. 220 107 PMID: 1425976

Sha et al (1996) Evaluation of 2,6-diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437), a protein kinase C inhibitor, as a modulator of P-glycoprotein-mediated resistance in vitro. Invest.New Drugs 13 285 PMID: 8824346

Sullivan et al (1992) 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain. Mol.Pharmacol. 41 38 PMID: 1732721

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