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说明： Selective non-transportable GlyT1 inhibitor
别名： (±)-NFPS
化学名： N-[3-([1,1-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine
纯度： ≥98% (HPLC)
生物活性 for NFPS
NFPS is a selective, non-transportable inhibitor of GlyT1 which displays no activity at GABA or glutamate receptors (IC50 values are 2.8, 9.8 and 56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Enhances the amplitude of the NMDA component of glutamatergic EPSCs.
R-enantiomer also available.
技术数据 for NFPS
| 分子量 | 393.45 |
| 公式 | C24H24FNO3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 405225-21-0 |
| PubChem ID | 5311283 |
| InChI Key | FDORQEIHOKEJNX-UHFFFAOYSA-N |
| Smiles | FC1=CC=C(C(OC2=CC=C(C3=CC=CC=C3)C=C2)CCN(C)CC(O)=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NFPS
参考文献 for NFPS
参考文献是支持产品生物活性的出版物。
Bergeron et al (1998) Modulation of N-MthD.-aspartate receptor function by glycine transport. Proc.Natl.Acad.Sci.USA 95 15730
Harsing Jr. et al (2003) The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study. Pharmacol.Biochem.Behav. 74 881
Mallorga et al (2003) Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine. Neuropharmacology 45 585 PMID: 12941372
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关键词: NFPS, NFPS supplier, Selective, non-transportable, GlyT1, inhibitors, inhibits, Glycine, Transporters, Monoamine, Neurotransmitter, (+/-)-NFPS, 2789, Tocris Bioscience
2 篇 NFPS 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NFPS 的部分引用包括：
DeBrouse et al (2013) Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site. Alcohol Clin Exp Res 37 223 PMID: 22934986
Romei et al (2016) Colocalization of neurotransmitter transporters on the plasma membrane of the same nerve terminal may reflect cotransmission. Brain Research Bulletin 127 100 PMID: 27565422
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