Neuropeptide AF (human)

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Cat.No. 1928 - Neuropeptide AF (human) | Ala-Gly-Glu-Gly-Leu-Asn-Ser-Gln-Phe-Trp-Ser-Leu-Ala-Ala-Pro-Gln-Arg-Phe-NH2 | CAS No. 192387-38-5
说明: Endogenous NPFF1 and NPFF2 agonist; antiopioid neuropeptide and MRGPRA agonist
别名: NPAF, Neuropeptide NPAF (human FMRFamide-related)
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文献 (2)

生物活性 for Neuropeptide AF (human)

Neuropeptide AF (human) is an endogenous antiopioid neuropeptide and agonist at NPFF1 and NPFF2 receptors. Implicated in pain modulation and endocrine functions. May also regulate metabolism via stimulation of β-adrenoceptor expression in adipocytes. Also MRGPRA agonist

技术数据 for Neuropeptide AF (human)

分子量 1978.19
公式 C90H132N26O25
序列 AGEGLNSQFWSLAAPQRF

(Modifications: Phe-18 = C-terminal amide)

储存 Desiccate at -20°C
CAS Number 192387-38-5
PubChem ID 90488726
InChI Key DYSIROANKWMSGC-KWFINLGMSA-N
Smiles [H]N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

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溶解性数据 for Neuropeptide AF (human)

溶解性 Soluble to 1 mg/ml in water

产品说明书 for Neuropeptide AF (human)

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参考文献 for Neuropeptide AF (human)

参考文献是支持产品生物活性的出版物。

Elshourbagy et al (2000) Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor. J.Biol.Chem. 275 25965 PMID: 10851242

Lefrere et al (2002) Neuropeptide AF and FF modulation of adipocyte metabolism. J.Biol.Chem. 277 39169 PMID: 12149260

Vilim et al (1999) Gene for pain modulatory neuropeptide FF: induction in spinal cord by noxious stimuli. Mol.Pharmacol. 55 804 PMID: 10220558

Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 66 570 PMID: 24867890


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关键词: Neuropeptide AF (human), Neuropeptide AF (human) supplier, Implicated, pain, modulation, antiopioid, neuropeptides, FF, AF, NPFF, Receptors, NPFF1, NPFF2, endogenous, agonists, MRGPRA, mas-related, gene, protein, coupled, agonism, NPAF, Neuropeptide, (human, FMRFamide-related), Miscellaneous/Non-selective, Opioids, FF/AF, Mas-related, G, Protein-Coupled, 1928, Tocris Bioscience

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