N,N-Dimethylsphingosine

Name: N , N -Dimethylsphingosine
Brand: Tocris Bioscience
SKU: 4640

Cat. No. 4640 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4640 has been discontinued.

View all Sphingosine Kinase products.

说明： Sphingosine kinase inhibitor

化学名： (2S,3R,4E)-2-(Dimethylamino)-4-octadecene-1,3-diol

纯度： ≥98% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for N,N-Dimethylsphingosine

N,N-Dimethylsphingosine is a competitive sphingosine kinase (SphK) inhibitor. Exhibits inhibitory activity in platelets and in cytosolic extracts from U937, Swiss 3T3 and PC12 cells. Selectively inhibits sphingosine phosphorylation; does not inhibit N-acylation, and displays no inhibitory effect on protein kinase C at concentrations that inhibit SphK. Increases the release of IL-1β and MCP-1 in cultured astrocytes; thought to mediate mechanical allodynia via this mechanism.

技术数据 for N,N-Dimethylsphingosine

分子量	327.55
公式	C₂₀H₄₁NO₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	119567-63-4
PubChem ID	5282309
InChI Key	YRXOQXUDKDCXME-YIVRLKKSSA-N
Smiles	O[C@@H]([C@H](CO)N(C)C)/C=C/CCCCCCCCCCCCC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for N,N-Dimethylsphingosine

分析证书/产品说明书

化学品安全技术说明书

参考文献 for N,N-Dimethylsphingosine

参考文献是支持产品生物活性的出版物。

Patti et al (2012) Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin. Nat.Chem.Biol. 8 232 PMID: 22267119

Edsall et al (1998) N,N-dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. Biochemistry 37 12892 PMID: 9737868

Yatomi et al (1996) N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. Biochemistry 35 626 PMID: 8555236

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关键词: N,N-Dimethylsphingosine, N,N-Dimethylsphingosine supplier, sphingosine, kinases, SphK, inhibitors, inhibits, neuropathic, pain, Sphingosine, Kinase, 4640, Tocris Bioscience

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