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Submit ReviewMDL 29951
说明： NMDA antagonist, acts glycine site
化学名： 2-Carboxy-4,6-dichloro-(1H)-indole-3-propanoic acid
生物活性 for MDL 29951
Potent, selective antagonist at the glycine-NMDA site (IC50 = 140 nM against glycine binding). Displays 2500-fold selectivity for the glycine vs. glutamate binding site.
技术数据 for MDL 29951
| 分子量 | 302.11 |
| 储存 | Store at RT |
| CAS Number | 130798-51-5 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MDL 29951
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参考文献 for MDL 29951
参考文献是支持产品生物活性的出版物。
Salituro et al (1992) 3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-MthD.-aspartic acid receptor associated glycine binding site. J.Med.Chem. 35 1791 PMID: 1534125
Stone (2000) Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. TiPS 21 149 PMID: 10740291
Rowley et al (1992) Synthesis of cis-4-amido and trans-4-amido 2-carboxytetrahydroquinolines, high affinity ligands at the glycine site of the NMDA receptor. Bioorg.Med.Chem.Lett. 371 1627
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关键词: MDL 29951, MDL 29951 supplier, NMDA, Receptors, 0467, Tocris Bioscience
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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