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LY 171883

Cat. No. 2140 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2140 has been discontinued.

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说明： Selective, orally active LTD4 antagonist
别名： Tomelukast
化学名： 1-[2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]ethanone
纯度： ≥99% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for LY 171883

Selective, orally active leukotriene D4 (LTD4) antagonist; inhibits binding of [3H]-LTD4 to guinea pig lung membranes (Ki = 0.63 μM). Acts as an agonist at peroxisome proliferator-activated receptors (PPARs).

技术数据 for LY 171883

分子量 318.37
公式 C16H22N4O3
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 88107-10-2
Smiles OC1=C(CCC)C(OCCCCC2=NN=NN2)=CC=C1C(C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for LY 171883

参考文献是支持产品生物活性的出版物。

Fleisch et al (1985) LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5-yl) butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist. J.Pharmacol.Exp.Ther. 233 148 PMID: 3981452

Aharony et al (1987) Inhibition of 3H-leukotriene D4 binding to guinea pig lung receptors by the novel leukotriene antagonist ICI 198,615. J.Pharmacol.Exp.Ther. 243 921 PMID: 2826761

Cannon and Eacho (1991) Interaction of LY171883 and other peroxisome proliferators with fatty-acid-binding protein isolated from rat liver. Biochem.J. 280 387 PMID: 1747111

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关键词: LY 171883, LY 171883 supplier, Selective, orally, active, LTD4, antagonists, CysLT1, Receptors, LY171883, Tomelukast, Leukotriene, and, Related, 2140, Tocris Bioscience

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